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Background and Purpose of SR3

The Schistosome Related Reagent Repository (SR3) has been launched by NIAID to serve as a central facility for the collection and long-term storage of schistosome and snail-host related reagents. This will allow scientists: 1) improved access to parasite, snail, and related reagents; and 2) availability of these standardized reagents in a renewable form. SR3 would be an additional resource to complement the WHO/UNDP/World Bank Schistosoma Genome Network and the TIGR Schistosoma mansoni Genome Project The purpose of this repository is to provide easy access to standardized and well-characterized material, generated by numerous investigators, towards a better understanding of the biology of the schistosome parasites and their intermediate snail hosts.

In June 2003, a contract supplement was awarded to the Biomedical Research Institute, Rockville, Maryland to establish the Schistosome Related Reagent Repository (SR3). This repository is an expansion of the schistosome life-cycle resource contract that has been maintained at the Biomedical Research Institute since 1995. This contract has provided life-cycle stages of several strains of the 3 medically important schistosomes- Schistosoma mansoni S. haematobium and S. japonicum. A Scientific Advisory Committee organized by the NIAID will provide oversight of the SR3’s operations, prioritize reagent acquisition and training needs, and act as a liaison to the schistosome community.

Types of schistosome and snail reagents maintained by the repository will include:

  • Molecular biology reagents: Genomic libraries, cDNA libraries, glycerol stocks and bacterial stabs of recombinant clones, recombinant plasmid DNA, oligonucleotide probes, PCR primers.
  • Immunologic reagents: antisera against schistosome products (storage only)
  • Other reagents to be added on a need-to basis: high density filters of gridded BAC, EST, and cosmid libraries, and cryopreserved transgenic parasites.

We hope the activities of the SR3 will make ready availability of schistosome reagents to other interested scientists and promote a sense of collaboration within the schistosomiasis research community worldwide.

For more information about SR3 operations, please visit the Basic SR3 operations page.

 
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