New Reagents

NIH NIAID Schistosomiasis Resource Center

New Research Reagents

Schistosoma haematobium, Egyptian Strain, Infected Mice
BEI Number: NR-46430

The Egyptian strain of Schistosoma haematobium was originally isolated circa 1950 from an unknown location in Egypt. The laboratory stock of the Egyptian strain of S. haematobium was later mixed with an isolate that is thought to be obtained from Abrawash (Cairo) by the Naval Medical Research Unit III in 1977. The current Egyptian strain of S. haematobium maintained at BRI is from a mixture of the 1977 stock and another Egyptian isolate obtained in the 1980s.

BALB/c or Swiss Webster mice undergo tail immersion with S. haematobium cercariae to introduce the parasite life stage of interest.

Biosafety Level 1. For research use only. Not for human use.

 

Schistosoma haematobium, Egyptian Strain, Egg-Injected (Bladder Wall) BALB/c Mice
BEI Number: 49104

Mice transdermally infected with S. haematobium develop liver and intestinal disease instead of urogenital schistosomiasis like humans. This limits the utility of mice for the study of urogenital schistosomiasis. Fu et al. (2012) described a model in which S. haematobium eggs are injected into the mouse bladder wall, which reproduces many aspects of human disease.

Female BALB/c mice undergo bladder wall injection with S. haematobium eggs to ensure deposition of the parasite life stage of interest.

Biosafety Level 1. For research use only. Not for human use.

BEI Resources is the web-based storefront for obtaining schistosomiasis research reagents from the Schistosomiasis Resource Center at Biomedical Research Institute. Check out the catalog of available materials and register at www.beiresources.org. BEI Resources products are provided at no cost to registered researchers.